2025
原著論文 / Original Papers
High glucose inhibits O-GlcNAc transferase translocation in early osteoblast differentiation by altering protein phosphatase 2A activity.
Sitosari H, Fukuhara Y, Weng Y, Zheng Y, He Y, Zheng X, Ikegame M, Okamura H*.
PTPA localized in Golgi apparatus plays an important role in osteoblast differentiation.
Zheng X, Weng Y, Satoh A, Tanai A, Ikegame M, Kimura K, Yoshitani N, Xie X, Okamura H*.
Angiogenin-induced osteoclastogenesis mediates bone destruction in oral squamous carcinoma.
Aoki K, Yoshitani N, Kurio N, Yoshioka N, Teramachi J, Ikegame M, Okamura H*, Ibaragi S.
P. gingivalis-infected macrophage EVs cause adverse pregnancy outcomes.
Tanai A, Fukuhara Y, Eguchi T, Kawai H, Ueda K, Ochiai K, Ikegame M, Okamoto K, Okamura H.
Gingipain regulates isoform switches of PD-L1 in macrophages infected with Porphyromonas gingivalis.
Zheng Y, Wang Z, Weng Y, Sitosari H, He Y, Zhang X, Shiotsu N, Fukuhara Y, Ikegame M, Okamura H*
O-GlcNAse transiently translocates to the cytoplasm and regulates osteoblast differentiation.
Zheng X, Tanai A, Sitosari H, Weng Y, Andini AD, Kimura K, Ikegame M, Okamura H*, Xie X.
2024
原著論文 / Original Papers
O-GlcNAcyalation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, and endoplasmic reticulum.
Weng Y, Wang Z, Sitosari H, Ono M, Okamura H*, Oohashi T.
-catenin binds to Gsk-3 in liquid-liquid phase separation compartment in HEK293 cells
Kato M, Tanai A, Fukuhara Y, Zheng X, Sitosari H, Yamamoto T, Ikegame M, Okamura H*.
Journal of Hard Tissue Biology, 33(4), 213-218, 2024
2023
原著論文 / Original Papers
Inhibition of protein phosphatase 2A by okadaic acid induces translocation of nucleocytoplasmic O-GlcNAc transferase.
Sitosari H, Morimoto I, Fukuhara Y, Weng Y, Zheng Y, Ikegame M, Okamura H.
Neuropilin 1 (NRP1) positively regulates adipogenic differentiation in C3H10T1/2 cells.
Yu Y, Uchida-Fukuhara Y, Weng Y, He Y, Ikegame M, Wang Z, Yoshida K, Okamura H, Qiu L.
Mechanical stretching determines the orientation of osteoblast migration and cell division.
Takemoto F, Uchida-Fukuhara Y, Kamioka H, Okamura H, Ikegame M.
2022
原著論文 / Original Papers
Histone demethylase Jmjd3 regulates the osteogenic differentiation and cytokine expressions of periodontal ligament cells.
Yu B, Wang R, Luo H, Yang D, Wang S, Yu Y, Okamura H, Qiu L.
Osteoblast Jmjd3 regulates osteoclastogenesis via EphB4 and RANKL signaling.
Wang R, Luo H, Yang D, Yu B, Guo J, Shao L, Okamura H, Qiu L.
Maternal gut microbe decelerates fetal endochondral bone formation by inducing inflammatory reaction.
Uchida-Fukuhara Y, Hattori T, Fu S, Kondo S, Kuwahara M, Fukuhara D, Islam MM, Kataoka K, Ekuni D, Kubota S, Morita M, Ikegame M, Okamura H.
Vestigil-like 3 plays an important role in osteoblast differentiation by regulating the expression of osteogenic transcription factors and BMP signaling.
Yuan H, Ikegame M, Fukuhara Y, Takemoto F, Yu Y, Teramachi J, Weng Y, Guo J, Yamada D, Takarada T, Li Y, Okamura H, Zhang B.
2021
総説 / Reviews
The role of extracellular vesicles throughout normal pregnancy and in relation to oral bacteria.
Tanai A, Okamura H.
Outer membrane vesicles of Porphyromonas gingivalis: novel communication tool and strategy.
Okamura H, Hirota K, Yoshida K, Weng Y, He Y, Shiotsu N, Uchida-Fukuhara Y, Tanai A, Guo J.
原著論文 / Original Papers
Extracellular vesicles of P. gingivalis-infected macrophages induce lung injury.
Yoshida K, Yoshida K, Fujiwara N, Seyama M, Ono K, Kawai H, Guo J, Wang Z, Weng Y, Yu Y, Uchida-Fukuhara Y, Ikegame M, Sasaki A, Nagatsuka H, Kamioka H, Okamura H, Ozaki K.
O-GlcNAcylation drives calcium signaling toward osteoblast differentiation: A bioinformatics-oriented study.
Weng Y, Wang Z, Fukuhara Y, Tanai A, Ikegame M, Yamada D, Takarada T, Izawa T, Hayano S, Yoshida K, Kamioka H, Okamura H.
2020
総説 / Reviews
Quorum-sensing molecule N-(3-Oxododecanoyl)-L-Homoserine lactone: An all-rounder in mammalian cell modification.
Guo J, Yoshida K, Ikegame M, Okamura H.
原著論文 / Original Papers
Inhibitory effect of retinoic acid receptor agonists on in vitro chondrogenic differentiation.
Sumitani Y, Uchibe K, Yoshida K, Weng Y, Guo J, Yuan H, Ikegame M, Kamioka H, Okamura H.
Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver.
Seyama M, Yoshida K, Yoshida K, Fujiwara N, Ono K, Eguchi T, Kawai H, Guo J, Weng Y, Haoze Y, Uchibe K, Ikegame M, Sasaki A, Nagatsuka H, Okamoto K, Okamura H, Ozaki K.
Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer.
Okusha Y, Eguchi T, Tran MT, Sogawa C, Yoshida K, Itagaki M, Taha EA, Ono K, Aoyama E, Okamura H, Kozaki KI, Calderwood SK, Takigawa M, Okamoto K.
Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer.
Ono K, Sogawa C, Kawai H, Tran HK, Taha EA, Lu Y, Oo MW, Okusha Y, Okamura H, Ibaragi S, Takigawa M, Kozaki K, Nagatsuka H, Sasaki A, Okamoto K, Calderwood SK, Eguchi T.
Outer membrane vesicles derived from porphylomonas gingivalis induced cell death with disruption of tight junctions in human lung epithelial cells.
He Y, Shiotsu N, Uchida-Fukuhara Y, Guo J, Weng Y, Ikegame M, Wang Z, Ono K, Kamioka H, Torii Y, Sasaki A, Yoshida K, Okamura H.
N-(3-oxododecanoyl)-homoserine lactone regulates osteoblast apoptosis and differentiation by mediating intracellular calcium.
Guo J, Wang Z, Weng Y, Yuan H, Yoshida K, Ikegame M, Uchibe K, Kamioka H, Ochiai K, Okamura H, Qiu L.
Loading history changes the morphology and compressive force-induced expression of receptor activator of nuclear factor kappa B ligand/osteoprotegerin in MLO-Y4 osteocytes.
Wang Z, Weng Y, Ishihara Y, Odagaki N, Ei Hsu Hlaing E, Izawa T, Okamura H, Kamioka H.
The inhibitory role of Rab11b in osteoclastogenesis through triggering lysosome-induced degradation of c-Fms and RANK surface receptors.
Tran MT, Okusha Y, Feng Y, Morimatsu M, Wei P, Sogawa C, Eguchi T, Kadowaki T, Sakai E, Okamura H, Naruse K, Tsukuba T, Okamoto K.
2018
総説 / Reviews
多彩な役割をもつ蛋白質脱リン酸化酵素PP2A
岡村裕彦
岡山歯学会雑誌, 36 (2), 25-36, 2018
原著論文 / Original Papers
Upregulated Osterix expression elicited by Runx 2 and Dlx5 is required for the accelerated osteoblast differentiation in PP2A Cα-knockdown cells.
Yang D, Okamura H, Qiu L.
Cell Biology International, 42(4), 403-410, 2018
Reduction of Protein Phosphatase 2A Cα promotes in vivo bone formation and adipocyte differentiation.
Yoshida K, Teramachi J, Uchibe K, Ikegame M, Qiu L, Yang D, Okamura H.
Molecular and Cellular Endocrinology, 470, 251-258, 2018
Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment.
Eguchi T, Sogawa C, Okusha Y, Uchibe K, Iinuma R, Ono K, Nakano K, Murakami J, Itoh M, Arai K, Fujiwara T, Namba Y, Murata Y, Ohyama K, Shimomura M, Okamura H, Takigawa M, Nakatsura T, Kozaki KI, Okamoto K, Calderwood SK.
PLoS One, 13(2), e0191109, 2018
2017
総説 / Reviews
Role of protein phosphatase 2A in osteoblast differentiation.
Okamura H, Yoshida K, Morimoto H, Teramachi J, Ochiai K, Haneji T, Yamamoto A.
原著論文 / Original Papers
PKR regulates LPS-induced osteoclast formation and bone destruction in vitro and in vivo.
Teramachi J, Inagaki Y, Shinohara H, Okamura H, Yang D, Ochiai K, Baba R, Morimoto H, Nagata T, Haneji T.
Oral Disease, 23(2), 181-188, 2017
Involvement of interleukin-23 induced by Porphyromonas endodontalis lipopolysaccharide in osteoclastogenesis.
Ma N, Yang D, Okamura H, Teramachi J, Hasegawa T, Qiu L, Haneji T.
Molecular Medicine Reports, 15 (2), 559-566, 2017
PKR induces the expression of NLRP3 by regulating the NF-B pathway in Porphyromonas gingivalis-infected osteoblasts.
Yoshida K, Okamura H, Hiroshima Y, Abe K, Kido JI, Shinohara Y, Ozaki K.
Experimental Cell Research, 354(1), 57-64, 2017
2016
原著論文 / Original Papers
Histone demethylase Jmjd3 regulates osteoblast apoptosis through targeting anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bim.
Yang D, Okamura H, Teramachi J, Haneji T.
Biochimica Biophysica Acta-Molecular Cell Research, 1863 (4), 650-659, 2016
Porphyromonas gingivalis attenuates the insulin-induced phosphorylation and translocation of forkhead box protein O1 in human hepatocytes.
Takamura H, Yoshida K, Okamura H, Fujiwara N, Ozaki K.
Archives Oral Biology, 69, 19-24, 2016
Protein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells.
Yang D, Okamura H, Morimoto H, Teramachi J, Haneji T.
Laboratory Investigation, 96(10), 1050-1062, 2016
2015
原著論文 / Original Papers
Double stranded RNA-dependent protein kinase is necessary for TNF-α-induced osteoclast formation in vitro and in vivo.
Shinohara H, Teramachi J, Okamura H, Yang D, Nagata T, Haneji T.
Journal of Cellular Biochemistry, 116 (9), 1957-1967, 2015
Histone demethylase Utx regulates differentiation and mineralization in osteoblasts.
Yang D, Okamura H, Teramachi J, Haneji T.
Journal of Cellular Biochemistry, 116 (11), 2628-2636, 2015
2014
原著論文 / Original Papers
Reduction of PP2A Cα stimulates adipogenesis by regulating the Wnt/GSK-3β/β-catenin pathway and PPARγ expression.
Okamura H, Yang D, Yoshida K, Teramachi J, Haneji T.
Biochimica Biophysica Acta-Molecular Cell Research, 1843 (11), 2376-2384, 2014.
Calcium hydroxide suppresses Porphyromonas endodontalis lipopolysaccharide-induced bone destruction.
Guo J, Yang D, Okamura H, Teramachi J, Ochiai K, Qiu L, Haneji T.
Journal of Dental Research, 93 (5), 508-513, 2014.
Preventive effect of Daiokanzoto (TJ-84) on 5-fluorouracil-induced human gingival cell death through the inhibition of reactive oxygen species production.
Yoshida K, Yoshioka M, Okamura H, Moriyama S, Kawazoe K, Grenier D, Hinode D.
PLoS One, 9 (11), e112689, 2014
Tumor necrosis factor-α induces interleukin-34 expression through nuclear factor-B activation in MC3T3-E1 osteoblastic cells.
Yu Y, Yang D, Qiu L, Okamura H, Guo J, Haneji T.
Molecular Medicine Reports, 10 (3), 1371-1376, 2014
2013
原著論文 / Original Papers
Protein phosphatase 2A Cα is involved in osteoclastogenesis by regulating RANKL and OPG expression in osteoblasts.
Okamura H, Yang D, Yoshida K, Haneji T.
FEBS Letters, 587 (1), 48-53, 2013
Protein phosphatase 2A Cα regulates osteoblast differentiation and the expressions of bone sialoprotein and osteocalcin via osterix transcription factor.
Okamura H, Yoshida K, Yang D, Haneji T.
Journal of Cellular Physiology, 228 (5), 1031-1037, 2013
Oral porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signalling pathway.
Ishikawa M, Yoshida K, Okamura H, Ochiai K, Takamura H, Fujiwara N, Ozaki K.
Biochimica Biophysica Acta-Molecular Basis of Disease, 1832 (12), 2035-2043, 2013
Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and osterix.
Yang D, Okamura H, Nakashima Y, Haneji T.
Journal of Biological Chemistry, 288 (47), 33530-33541, 2013.
2012
原著論文 / Original Papers
Interaction between PKR and PACT mediated by LPS-inducible NF-B in human gingival cells.
Yoshida K, Okamura H, Hoshino Y, Shono M, Yoshioka M, Hinode D, Yoshida H.
Journal of Cellular Biochemistry, 113 (1), 165-173, 2012
PKR plays a positive role in osteoblast differentiation by regulating GSK-3 activity through a -catenin-independent pathway.
Yoshida K, Okamura H, Ochiai K, Hoshino Y, Haneji T, Yoshioka M, Hinode D, Yoshida H.
Molecular and Cellular Endocrinology, 361 (1-2), 99-105, 2012
2011
原著論文 / Original Papers
Intermedilysin induces EGR-1 expression through calcineurin/NFAT pathway in human cholangiocellular carcinoma cells.
Susilowati H, Okamura H, Hirota K, Shono M, Yoshida K, Murakami K, Tabata A, Nagamune H, Haneji T, Miyake Y.
Biochemical and Biophysical Research Communications, 404 (1), 57-61, 2011
Reduction of Protein Phosphatase 2A Cα enhances bone formation and osteoblast differentiation through the expression of bone-specific transcription factor Osterix.
Okamura H, Yoshida K, Ochiai K, Haneji T.
Bone, 49 (3), 368-375, 2011
